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3.2 Polyamines Polyamines (PAs) are important metabolites produced by gut bacteria

Mucus and antimicrobial peptides secreted by goblet cells, as well as immunomodulatory proteins secreted by Paneth cells, can help to prevent the adhesion of pathogenic bacteria and viruses in the intestinal lumen ( eff ) cells and T reg cells ( Figure 1

92,93 The transamination product of Asp, asparagine (Asn), is more permeable than Asp, but when cellular asparaginase activity is inhibited, Asn cannot be converted to Asp

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