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Because of this challenge to weight maintenance, it is important to develop adjunctive treatments to support patients in achieving their sustained weight-loss goals

Clin Endocrinol 52:181186 Walker JL, Ginalska-Malinowska M, Romer TE, Pucilowska JB, Underwood LE (1991) Effects of the infusion of insulin-like growth factor I in a child with growth hormone insensitivity syndrome (laron dwarfism)

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Mechanisms and outcomes Vitamin B12 interventions are commenced upon diagnosis of low B12 status, typically comprise high dose injections until levels are within acceptable range, and then the intervention is changed to a maintenance dose that is typically administered every 3 months ad infinitum