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At present, natalizumab, a humanized monoclonal antibody against the cell adhesion molecule 4-integrin, is advantageously used in the treatment of multiple sclerosis and Crohn's disease (24)

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In contrast, the related compound AOD-9604 underwent six human studies between 2001 and 2007, and while it was found safe and well-tolerated, it failed to produce significant fat loss compared to placebo

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However, there was no significant difference between treatment groups when the macrophages were incubated with primed PBMCs

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