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Several lines of evidence highlighted the role of neuroinflammation and exaggerated inflammatory response in ADHD, where elevated levels of pro-inflammatory mediators, including TNF- in children with ADHD were linked with the enhanced intensity of symptoms, such as inattention (Oades et al

Fluoxetine reduces the mRNA expression of c-Fos through the PI3K/AKT signaling pathway after acute application at concentrations below 1 M, while the treatments with the higher doses (above 5 M), it increases the gene expression of c-Fos via the MAPK/ERK signaling pathway in astrocytes

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Animals were fed commercially available rodent diet [(standard diet (SD)] sourced from Top Feeds Ltd, Ibadan Nigeria)