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In the ventrolateral preoptic area, morphine reduces the firing rate and hyperpolarizes sleep-promoting neurons (as assessed by sensitivity to norephinephrine treatment) but has no effect on non-sleep-promoting interneurons (Wang et al., 2013)

Macronutrient composition is another essential element

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Insulin resistance, a common characteristic of obesity, can also influence dosage decisions, particularly with GLP-1 agonists, as they directly impact insulin secretion and sensitivity