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In obesity and insulin resistance, mitophagy markers, including LC3BII, Parkin, FUNDC1, and BNIP3, are generally reduced in both human and animal studies, reflecting compromised mitochondrial turnover

Nutr Cancer 72:11351145

Consequently, if maintaining a daily L-carnitine feeding regime with CHO has an additive effect on muscle carnitine content, L-carnitine feeding for 100 days could increase muscle carnitine content by an additional 10%, which we believe could have a significant metabolic impact in contracting skeletal muscle. In the other comprehensive Stephens Group study they found that muscle total carnitine content was not reduced 24 h after a 15% increase, suggesting that a daily increase in muscle carnitine content can be maintained