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When the gut microbiome is out of balance, it can lead to increased inflammation and altered signaling to the brain

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These findings are consistent with previous epidemiologic studies establishing obesity as a major risk factor for HS [10] and demonstrating increased TG concentrations and reduced HDL-C concentrations in HS populations, thereby reinforcing the close association between HS and an atherogenic lipid profile [5, 7, 8, 11, 12]

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