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Autoimmune diseases like Sjgrens syndrome, systemic lupus erythematosus, and rheumatoid arthritis are often associated with increased levels of circulating DNA, with the disease index of Sjgrens syndrome correlating with circulating DNA levels [87]

LTQ first reacts with the lysine -amino group to form a substrate-LTQ Schiff base adduct, which then undergoes abstraction of -proton to form quinolaldimine