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Pulmonary ARDS is usually characterized by extensive ground-glass opacification and asymmetric lung consolidation, while extrapulmonary ARDS is characterized by symmetrical ground-glass opacification distributed in perihilar regions ( 2.3 Heterogeneity in the onset time of ARDS The Berlin definition sets the onset of ARDS as within one week of the occurrence or exacerbation of the underlying injury ( 2.4 Biomarker heterogeneity Biomarkers of ARDS can not only indicate the pathogenesis and progression of the disease, but also conduce to identify ARDS subgroups and provide targeted treatment ( In ARDS, RAGE reflects alveolar epithelial damage, whereas Ang-2 is a marker of endothelial cell activation and increased capillary permeability

Its highest expression is on the luminal surface of the proximal tubules in the kidney, whilst the bile ducts, bile canaliculi, and endothelial cells of the nervous system capillaries also have high expression (Shiozawa et al., 1989

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