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Laurel Campbell, with West Tennessee Medical Group Primary Care & Pediatrics | Dyersburg, shares some insight below

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Supplementation with NAD + could slow down axonal degeneration and demyelination, but did not change the level of macrophage infiltration after amputation

In one aspect of the invention, one or more NNMT inhibitors (such as a cation of Formula I or IA, or otherwise disclosed herein) is contacted with a cell expressing NNMT concurrently with one or more chemical entities (e.g., nicotinamide riboside, nicotinamide mononucleotide) that increase intracellular NAD+ levels to provide muscular therapy