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This multi-layered regulatory mechanism weakens the differentiation of naive T cells into anti-tumor Th1 cells while promoting their differentiation into pro-tumor Th2 cells

5.7 Nanotechnology: precision control of the microbiota-metabolite axis to boost cancer immunotherapy Nanotechnology transforms cancer immunotherapy by resolving key limitations of microbial metabolite-based interventionspoor bioavailability, off-target toxicity, inconsistent microbiota crosstalkvia engineered carriers that enable targeted metabolite delivery, controlled release, and selective gut-tumor-microbiome modulation