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Description

Our results demonstrated that the activity of the wild-type HK2 promoter was significantly upregulated upon HMGA1 overexpression, which was abolished following mutation of the HMGA1 binding sites (Fig

doi: 10.3390/nu17121961 187 WangY.GaoL

Glutamine supports immune functions too: for example, T-cell activation requires Alanine-Serine-Cysteine Transporter 2-mediated glutamine uptake to engage mTORC1 and drive proliferation, and glutamine deprivation blocks T-cell proliferation and cytokine production, so complete glutamine elimination should rather be avoided 357