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Persistent organic pollutants and diabetes: A review of the epidemiological evidence

VHL alterations in RCC cells lead to the activation of hypoxia-inducible factors and their downstream target vascular endothelial growth factor, and to the reprogramming of multiple cell death pathways and metabolic weakness, including ferroptosis, which are associated with targeted therapy or immunotherapy

Cessation of mercury exposure and chelation therapy are the cornerstones across all studies, effectively removing mercury concentrations and reducing proteinuria