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A stromal lysolipid-autotaxin signaling axis promotes pancreatic tumor progression

In doxorubicin-induced cardiotoxicity, PSG-1 confers cardioprotection by selectively suppressing the mitochondrial intrinsic apoptotic pathwayevidenced by enhanced MnSOD activity, preservation of mitochondrial membrane potential, inhibition of mitochondrial permeability transition pore (mPTP) opening, and attenuated cytochrome c release into the cytosol (Ubaidillah et al., 2016)