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More than 50 cells were scored per condition per experiment ( n = 3)

Endothelial-to-mesenchymal transition (EndMT) is driven by similar signaling mechanisms as EMT (Snail-1, Slug (Snail-2) and Twist-1/2) and leads to the loss of characteristic endothelial markers PECAM-1/CD-31, VE-cadherin, vascular endothelial growth factor receptor 2 (VEGFR2) and endothelial nitric oxide synthase (eNOS)

Wuppermann 31 studied fibrinolysis in subjects injected with POL and found a slight, statistically insignificant hyperfibrinolysis in blood drawn from the antecubital vein

doi: 10.1186/s12872-025-04749-x Summary Keywords thrombus-derived exosome, M6A, LncRNA FENDRR, ferritinophagy, p53, NCOA4, single cell analysis, macrophages Citation He Y, Ai L, Zhou Y, Huang J, Long X and Wu Q (2025) Multi-omics approach to personalised treatment: insights into thrombus-derived exosome regulation in cardiomyocyte ferritinophagy