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Despite being present in trace amounts, both deficiency and excess of Se can significantly affect the nervous system by influencing neuronal activity

(60), which can lead to microbial translocation, systemic inflammation, and increased permeability of both the intestinal and blood-brain barriers (BBB), creating a vicious cycle (6165)

Erebosis is defined by the gradual degradation of the cytoskeleton, cell adhesion molecules, organelles, and DNA, culminating in cell death

Using this model, it was found that a high-fat diet could aggravate the ferroptosis process and, together with ER stress, worsen the development of pancreatitis