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Arginine starvation impairs mitochondrial respiratory function in ASS1-deficient breast cancer cells

Most heavy metals at high concentrations exhibit harmful effects on the central nervous system (CNS), energy metabolism, ion transporters, cardiovascular system, respiratory system, reproductive system and vital organs such as lungs, liver, brain and kidney [5,6]

The rate-limiting step in this pathway is indole 2,3-dioxygenase (IDO1), a pleiotropic enzyme with complex effects, including immunoregulation, typically as a negative regulator of inflammation and immunization (31, 32)

Lisbon: Woodhead Publishing (2019)