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Breathing and heart rate are measured in order to remove variance that correlates with these rhythms

Diagnosis typically involves blood tests (e.g., homocysteine, B vitamins) and genetic testing

Ikegami, K., Refetoff, S., Van Cauter, E

Much to our delight, however, the introduction of the electron-withdrawing substituent CF 3 (catalyst ( R )- 1d ) and C 2 F 5 (catalyst ( R )- 1e ), rather than the iodo-substituent of ( R )- 1c at the 3,3-position of the binaphthyl scaffold, resulted in a nearly complete conversion after the same reaction time, with excellent enantioselectivities (98% and 94% ee in entries 4 and 6, respectively)