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Some medications and supplements can cause even more profound changes: Bright orange : May result from rifampin or phenazopyridine Blue or green : Possible side effects of medications like amitriptyline or propofol Dark brown : Can occur with antimalarials or laxatives According to the Mayo Clinic (2022), medications and supplements frequently alter urine color and should be considered before assuming a medical concern [Mayo Clinic]

1 If vitamin B 12 deficiency coexists with folate deficiency, vitamin B 12 should be replaced first to prevent subacute combined degeneration of the spinal cord