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But, in some cases, like severe deficiency, shots might be given through a vein

But a better choice is combining adenosylcobalamin and hydroxocobalamin, a precursor of vitamin B12 that benefits the myelin nerve sheath and supports mitochondrial health

Lipton J, Megerian JT, Kothare SV, Cho YJ, Shanahan T, Chart H, et al

Phase Initial 4 weeks Daily Dose 300 mcg Volume 0.18 mL Units (U-100) 18 units Phase Maintenance (weeks 5-12) Daily Dose 500 mcg Volume 0.30 mL Units (U-100) 30 units Phase Optional extension Daily Dose 300-500 mcg Volume 0.18-0.30 mL Units (U-100) 18-30 units This summarizes the published research-context dose range (commonly cited 300-500 mcg/day)