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Furthermore, in addition to OXT regulation, a lipopolysaccharide (LPS)-induced depression-like behavior mouse model demonstrated that inhibiting CD38 improved neuroinflammation, microglial activation, synaptic defects, and Sirt1/STAT3 signaling, thereby improving depression-like behavior [13]

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In addition, T2D is the result of a complex interaction of environmental and genetic factors, being difficult to establish the role of each one in the pathogenesis of diabetes and in the levels of IGF-1