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16 Among them, protein tyrosine phosphatase 1B (PTP1B) is a widely expressed non-receptor PTP, which is associated with the endoplasmic reticulum by interaction through the C-terminal domain

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We predicted that, at higher PDI concentrations, a 1-Cys mechanism gets more predominant over a 2-Cys mechanism since, under such conditions, reduced PDI should more likely win the race of nucleophilic attack to a sulphenylated C P against the C R residue of the same GPx7 molecule (Fig

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