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However, their therapeutic potential could be limited as a protracted use will lead to tolerance to analgesic effects requiring escalating doses that is associated with side effects such as respiratory depression

Growing evidence suggests that CRC cells exploit specific metabolic adaptation mechanisms to cope with the microenvironments of distant organs, thereby enhancing their invasiveness and metastatic colonization capacity

9:e1001169

The neuroprotective effect of dimethyl fumarate in an MPTP-mouse model of Parkinsons disease: involvement of reactive oxygen species/nuclear factor-kappaB/nuclear transcription factor related to NF-E2