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Interestingly, metronidazole gel has been found to be effective in SD and could be trialled in this case in the future if needed

Available from: [DOI] [PubMed] [Google Scholar] 163.Gleadle JM, Ebert BL, Firth JD, Ratcliffe PJ

That means three things in practice

The data indicate that the hydrogen bonds formed in this binding mode are not very reliable, and the fluctuations in the RMSD during the latter part of the simulation confirm the instability of CME_c