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The application of NaBPC157 leads to significantly reduced pathomorphological findings of antracyclin cardiomyopathy (severe damage of myocytes and vessel walls, and vacuolisation) after single, and in greater extent, after multiple doxorubicin administration

Pyruvate is transferred to mitochondria under aerobic conditions and oxidized to acetyl-CoA via the pyruvate dehydrogenase complex (PDHC) to accelerate aerobic oxidation