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The Bottom Line: Compelling Mechanisms Demand Rigorous Human Investigation BPC-157 presents a fascinating scientific paradox: extensive preclinical evidence spanning three decades demonstrates pleiotropic effects across multiple neurotransmitter systems, with antidepressant efficacy exceeding standard drugs in animal models, anxiolytic effects without dependence liability, neuroprotection in stroke and neurodegeneration models, and reversal of schizophrenia-like cognitive deficits

Based on all transcripts, the profiles from the M and C groups could be well discriminated at the PCA 1 level, which could explain up to 99.06% difference (Supplementary Figure S1B)

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