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Organotypic hippocampal slice cultures (OHSC) Mice (P6-8) were decapitated, brains were aseptically removed, and hippocampi were dissected under sterile conditions in ice-cold isolation buffer (pH 7.2) containing Gey's balanced salt solution (Thermo Fisher Scientific, Dreieich, Germany, #J67569.K2), 1 mM kynurenic acid (a NMDA receptor antagonist

When levels are low, symptoms such as fatigue, weakness, and brain fog may arise

Undoubtedly, GPX4 is the core regulator of ferroptosis

Genetic Factors: in Biotransformation of Drugs Genetic influences: Variation in drug metabolism rates or in receptor sensitivity: Metabolism : Patients can be categorized as either rapid or slow acetylators