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Even more recently, a key role for ACO during the sex determination of cucumber flowers was discovered ( Transcriptional Regulation of ACO Despite the fact that ACO expression has been observed to be temporally and spatially regulated (e.g., during tomato flower and fruit development

Reconciling these findings is not straightforward but may relate to two arguments

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Since the pathways involved in mitochondrial metabolism, calcium buffering, mitochondrial dynamic (mitochondrial trafficking through the axons, mitophagy, fusion and fission), regulation of apoptosis and oxidative stress are essential to an adequate differentiation, development and maturation of CNS, the recapitulation of all these processes in brain organoids is a major challenge