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JAK inhibitors [289] and other small molecule therapeutics have emerged as important alternatives for patients who have experienced biologic therapy failure or intolerance, offering advantages of oral administration convenience and multi-target anti-inflammatory effects

There is a qualitative increase in biliary excretion of compounds with higher molecular weight (Hirom 1972, Klaassen, 1981), thus conjugation to metabolites that are more polar and ionic than the parent drug often enhances the bile/plasma ratio of a metabolite relative the parent drug

Try to avoid triggers Gout is often brought on by external stresses, so being aware of these and avoiding them where possible can assist in preventing further attacks

Amasya G, Aksu B, Badilli U, Onay-Besikci A, Tarimci N