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Collectively, age-related inflammatory states, OS, metabolic disorders, and environmental pollutants appear to contribute to ovarian dysfunction by inducing pyroptosis in granulosa cells (Figure 5B)

Consume quality protein from fish, chicken, and beef for supplying glutamate and glycine

Reactive oxygen species (ROS), produced via GSH-mediated pathways, can serve as danger-associated molecular patterns, stimulating dendritic cells and promoting T-cell expansion [82]

Numerous studies have demonstrated that adherence to a MeDi, rich in diverse nutrients and phytochemicals, exerts anti-inflammatory, antioxidant, and anti-atherosclerotic effects, thereby lowering cardiovascular and cerebrovascular risk (Tuttolomondo et al., 2019)