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[4] Why Vitamin B12 Can Cause Gastrointestinal Symptoms The mechanisms underlying gastrointestinal side effects from vitamin B12 supplementation are not fully established, but several factors may contribute to stomach discomfort in susceptible individuals

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What harm can having too little of a vitamin do

A randomized, double-blind, placebo-controlled trial in 191 older adults (75 years) with moderate vitamin B 12 deficiency (serum cobalamin concentrations of 107-210 pmol/L) without anemia provided participants with 1 mg/day of cyanocobalamin for one year (94)