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Molecular docking simulations were conducted to analyze the binding interactions, affinities, and inhibition constants of these compounds with GSTP1

Yet, much of the mechanistic findings rely on supraphysiological Mn doses in vitro and need confirmation at physiologically relevant Mn concentrations in vivo

As uric acid builds up, it can accumulate in the joints, causing gout pain, or back up into the kidneys and contribute to kidney stones

ABOUT LEUKODYSTROPHY: There are over 50 types of leukodystrophy, a neurodegenerative family of diseases that affects the development and/or maintenance of the central nervous systems myelin sheath