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Major progress in our understanding, based on increasingly more precise identification of cell types and intercellular signaling as well as of intracellular molecular cues at play in SSc physio-pathology has spurred enthusiasm in the scientific community and has led to the recent approval of therapeutic agents that may alter the disease course

Acris, Herford, Germany) antibodies were used, as described previously 20

Step 2: Pinch the skin Using your non-dominant hand, pinch a one to two inch fold of skin at the cleaned injection site