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For instance, in one study, mice that were given large oral doses of 0.91.4 grams per pound (23 grams per kg) of body weight experienced difficulty breathing and multi-organ failure ( Whats more, giving large doses to pregnant rats was shown to cause pregnancy loss or developmental problems in their offspring ( Intakes of such large amounts are arguably uncommon in humans, other than potentially in cases of supplement overdoses

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In another study of 147 patients with painful DPN and an average daily pain (ADP) score 4, the ADP score decreased more in patients treated with gabapentin extended-release formula than in those treated with placebo (gabapentin, 2.76