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(PubMed) Ashton E, Windebank E, Skiba M, et al

Efficacy endpoints included changes in liver fat on MRI-PDFF, liver stiffness on MRE, and liver enzymes

High level of homocysteine in the blood (Hyperhomocysteinemia)

Therefore, it seems possible that estrogen receptor alpha may interact with IGF-I/insulin signaling pathways, to promote neuroprotective effects in brain