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Therefore, it is possible that the inconsistency is due to non-specific or polar effects instead of the loss of GSH synthesis

Gene set enrichment analysis with topGO

Our results support the existence of defense mechanisms for the studied species

390 Furthermore, arginine depletion in a specific TME can compromise macrophage mitochondrial function, polarizing cells toward an inflammatory phenotype and demonstrating the profound impact of metabolite-driven immunomodulation