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Temporal subtyping thus offers a useful descriptive framework for cutaneoushepatic involvement but, given the limited sample size, does not support firm conclusions regarding prognosis or rash phenotype

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To confirm these findings we tested the effect of elevated glutathione levels on in planta SA accumulation in a different experimental system: in this case tobacco leaf discs (diameter 1.5 cm) were continuously exposed to 2 mM or 5 mM OTC for 1, 2 or 3 days ( Figures S1, S2 )