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doi: 10.1530/REP-13-0594

Ortega, R., Deves, G

It can be seamlessly integrated with other treatments and therapies to enhance their effectiveness

IDO inhibits the function of immune cells through a specific L-Trp depletion pathway, where L-Trp depletion by IDO leads to its dissociation with L-Trp tRNA, thus activating general control non-derepressible 2 (GCN2) due to the presence of its allosteric regulatory site which senses free tRNAs (47, 48)