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However, because EPCAM deletions predominantly affect MSH2 expression, further research is needed to refine cancer risk estimates and optimize screening protocols for affected individuals ( The autosomal dominant inheritance of LS results in a 50% probability of passing the condition to offspring, making genetic testing and counseling essential for at-risk families

Furthermore, a statistically significant correlation (p=0.036) was observed between elevated abdominal circumference and the presence of the miRNA-499a polymorphism in the group with DKD, indicating a possible involvement of this marker in the regulation of processes related to central adiposity and chronic inflammation

Interactive tree of life (iTOL) v3: an online tool for the display and annotation of phylogenetic and other trees

ML planned, supervised the experiments, and helped wrote the manuscript