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Studies in KRAS G12D , sst2 hybrid mice demonstrated that PI3K/AKT signaling activates NF-B signaling and activates KRAS, promoting the release of CXC chemokine ligand 16 (CXCL16) and IL-6, ultimately leading to the progression of pancreatic ductal adenocarcinoma (PDAC)

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Positive family environment predicts improvement in symptoms and social functioning among adolescents at imminent risk for onset of psychosis