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Acknowledgements This work are financially supported by Chongqing Research Program (cstc2018jcyjAX0742) of Basic Research and Frontier Technology, Scientific and Technological Research Program (KJQN201900521) of Chongqing Education Committee, Scientific Research Fund (2019YJ0307) of Sichuan Provincial Science and Technology Department and Dazhou Municipal Science Project (18YYJC0002) of Technology Bureau Application Foundation

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tRNA modifying enzymes, NSUN2 and METTL1, determine sensitivity to 5-fluorouracil in HeLa cells