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Although these mechanisms have been predominantly characterized in non-tumor systems, they provide important conceptual frameworks for understanding the directionality and execution of mitochondrial transfer under metabolic stress

Vitamin C was shown to synergize with DNMTi treatment in a TET2-dependent manner to increase 5hmC, and drive DNA hypomethylation to further increase ERV expression and enhance apoptosis of leukemia and solid tumor cell lines (Liu et al., 2016)

The cells were filtrated through a 70-m cell strainer and washed with cold PBS buffer to remove cell clumps and debris

j-k , Serum tGSH (no tumor vs