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Interestingly, Acrylate copolymer promoted a dual effect related to its time of exposure in MucilAir-HF model: a downregulation of some released inflammatory biomarkers at 30 min/day exposure (Figure 5), whereas it triggered an upregulation profile at 6h/day exposure (Supplementary Figure S1)

Additionally, curcumin interacts with DNMT1s catalytic thiolate to target the enzyme directly, diminishing methylation in various cancer models (Liu et al