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- March 30, 2026 , , ., , , .

In rat cardiomyocytes, zinc overload elevates ROS and disrupts mitochondrial membrane potential, triggering PINK1/Parkin-mediated mitophagy and impairing mitochondrial dynamics and biogenesis, with mitofusin 2 (Mfn2) playing a protective role in mitigating zinc-induced mitochondrial damage 151