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suggests that aging reduces BHB levels, but endurance exercise can counteract this decline by promoting ketone production

During the early stages of APAP-induced liver injury, stressed and damaged hepatocytes release various endogenous DAMPs, such as HMGB1, 75 nuclear DNA fragments, 76 uric acid, 77 mitochondrial DNA, 76 ATP, and heat shock protein-70, an inducible stress response protein that is translocated to the cell surface and released during cellular stress or necrotic death

Similarly, treatment with AC markedly halted DU-145 and PC-3 prostate cancer cell proliferation and migration by downregulating the HMGB1/receptor for advanced glycation end products (RAGE) signaling cascade and its downstream transforming growth factor-beta I/II (TGF-I/II)/SMAD family member 2/3 (Smad2/3) pathway