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Clinical Applications (Experimental/Off-Label) Tendinopathies (Achilles, rotator cuff, patellar tendon), ligament injuries Muscle tears IBD (Crohns, ulcerative colitis) Leaky gut syndrome NSAID-induced gastric injury Post-operative recovery TBI, stroke (early animal evidence) Long COVID GI/neuro symptoms (theoretical) Note: These are off-label, experimental, based largely on animal studies, small human case studies

If left untreated, low vitamin B-12 levels can impact a persons energy levels, concentration, memory, and mood

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Despite the individual variability, a specific cognitive profile of subjects with DS is reported in the literature: communication skills are generally found to pose the most significant challenges, non-verbal reasoning is a relative strength 22 , daily living skills are somewhat stronger, and socialization is the strongest adaptive skill 23,24,25