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Here, we shall describe how the pressures of development are altering the city's visual character and its intangible cultural values, such as its sense of place, community spirit, and social fabric

doi: 10.1053/j.jrn.2012.08.012

However, these effects are not confined to the intestinal microenvironment, as it has been shown that butyrate produced by gut microbiota induces the expression of mouse -defensin 14 in pancreatic islets, which in turn drives the activation of regulatory macrophages and prevents the development of T1D in a mouse model (130)