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Description

Its common in the Middle East, South Asia, the southern Mediterranean region, and Africa

Disease in females is possible through mutations in both X chromosomes and, in older women, age-related skewing of X-chromosome inactivation in erythroid precursors

Acts as a macrophage DAMP molecule like MSU crystals to promote hyperuricemia and its complications ( via NLRP3 inflammasomes in macrophages ( UA activates phagocytosis by macrophages MSU crystals promote phagocytosis by macrophages