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Nasal biotransformation of xenobiotics has been addressed in the literature as many biotransformation enzymes including cytochrome P450 1B1 and glutathione S transferase P1 have been detected in nasal mucosa of humans in levels at least as abundant as in the liver [63]

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Additionally, JAK3 and STAT5B mutations impair Foxp3 expression, disrupting regulatory T cell (Treg)-mediated immune tolerance

After the ligation of left bronchus and the removal of the left lung tissues, the left lung tissues were immersed and fixed in 10% neutral formaldehyde for 48 h, followed by standard procedures of paraffin embedding and sections preparation