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As discussed above, energy metabolism dysfunction is a characteristic sign of ALS disease and defects in skeletal muscle energy metabolism deeply contribute to disease progression (Dupuis et al., 2011)

It is a member of the class-1 pyridine nucleotide-disulfide oxidoreductase family

Other mitochondria-targeted drugs (i.e., metformin and phenformin) have been used in combination with AZD3965 in brain cancer studies 54

RNA extraction and quantitative real-time polymerase chain reaction (RT-qPCR) Tissues from challenged mice were harvested and placed in 1 mL TRIzol Reagent in 2 mL RNase/DNase-free Omni tubes (Omni International), which contained beads for homogenization